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Cat. No.	Product Name	Target	Signaling Pathways
T25374	Emofolin sodium NSC139490,MeTHHF disodium,NSC-139490,NSC 139490
	Emofolin sodium is the sodium salt of a synthetic antimetabolite analogue of folate with antineoplastic activity，which competes for the folate binding site of the enzyme dihydrofolate reductase, resulting in inhibition of tetrahydrofolate synthesis, deple
T69199	Homopteroic Acid
	Homopteroic Acid is an intermediate in the synthesis of Homofolic Acid which inhibits the growth of L1210 mouse leukemia cells when intracellular folates are acquired via the high-affinity folate binding protein.

化合物

Emofolin sodium

Cat.No: T25374

Synonym: NSC139490,MeTHHF disodium,NSC-139490,NSC 139490

Species：

Expression System：

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Cat. No.	Product Name	Species	Expression System
TMPY-01815	FOLR1 Protein, Human, Recombinant (His) FBP,Folate Binding Protein,fo...	Human	HEK293 Cells
	FOLR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is A0A024R5H1.
TMPJ-00147	FOLR1 Protein, Human, Recombinant (hFc) Folate receptor 1,Folate receptor,Fola...	Human	HEK293 Cells
	FOLR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-75 kDa and the accession number is P15328.
TMPY-06929	FOLR1 Protein, Human, Recombinant (His & Avi), Biotinylated Folate Binding Protein,folate...	Human	HEK293 Cells
	FOLR1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 27.83 kDa and the accession number is NP_057937.1.
TMPY-06928	FOLR1 Protein, Human, Recombinant (hFc & Avi), Biotinylated FOLR,Folate Binding Protein,f...	Human	HEK293 Cells
	FOLR1 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 53.11 kDa and the accession number is NP_057937.1.
TMPJ-00148	FOLR1 Protein, Rhesus macaque, Recombinant (His) FR-alpha,Adult folate-binding protein<...	Rhesus	HEK293 Cells
	FOLR1 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 28-38 kDa and the accession number is F7BP60.
TMPK-00150	FOLR1 Protein, Human, Recombinant (His & Avi) Folate receptor 1,Folbp1,Folate receptor a...	Human	HEK293 Cells
	Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into t...
TMPJ-01299	RTBDN Protein, Human, Recombinant (His) Retbindin,RTBDN	Human	HEK293 Cells
	Human Retbindin is a 229 amino acid secreted protein that belongs to the folate receptor family. The gene that encodes retbindin exists as two alternatively spliced isoforms. Retbindin is first expressed in retina. It may play a role in binding retinoids and other carotenoids as it shares homology with;riboflavin binding proteins. RTBDN gene was first identified in a study of human eye tissues.
TMPJ-01118	GNMT Protein, Human, Recombinant (His) GNMT,Glycine N-Methyltransferase	Human	E. coli
	Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyzes the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine, playing an important role in maintaining normal AdoMet levels. GNMT is highly expressed in liver. As a major folate-binding protein, GNMT takes part in the detoxification pathway. Defects in GNMT are the cau...
TMPK-00585	FOLR4/Juno Protein, Human, Recombinant (His) Folate receptor 4,FR-δ,Folbp3,FR-delta,Izumo1r,Juno...	Human	HEK293 Cells
	Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor. FOLR4/Juno Pro...
TMPK-01171	FOLR4/Juno Protein, Mouse, Recombinant (His) Juno,FOLR4, LOC390243,Folate receptor 4,FR δ,FR-del...	Mouse	HEK293 Cells
	Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor. FOLR4/Juno Pro...